Table 8 Studies evaluating maternal and neonatal outcomes in patients receiving oral misoprostol vs. oxytocin for IOL in term PROM
From: Is there a role for oral misoprostol in labor induction for prelabor rupture of membranes at term?
Study | Number of patients receiving Oral Misoprostol and dosing protocol | Primary outcome | Results of primary outcomes. | Maternal outcomes | Neonatal outcomes |
|---|---|---|---|---|---|
Butt et al., 1999 [20] | 54 50 mcg orally every 4 h. | Interval from induction to delivery. | Longer induction to delivery interval (720 vs. 501 min p < 0.007) | No differences in the first, second, or third stages of labor. No differences in the mode of delivery or 2nd degree of tears. | No differences |
Crane et al., 2003 [21] | 102 75 mcg orally every 4 h. | Interval from induction to vaginal delivery | Longer induction to delivery interval (737 min vs. 573 min p < 0.04) | No difference in the rate of vaginal birth within 24 h of induction. No difference in the mode of delivery. Less hyperstimulation. Increased rates of patient satisfaction | No difference in neonatal outcomes. |
Mozurkewich 2003 [22] | 152 100 mcg orally every 6Â h. | Cesarean delivery | No difference in the rate of cesarean delivery | No difference in time from induction to delivery (714Â min vs. 708Â min) Less PPH | More infants received IV antibiotics No differences |
Anjum et al., 2016 [23] | 142 100mcg orally every 6Â h | Rate of vaginal delivery | No difference in the rate of vaginal delivery | No difference in the interval from induction to delivery (492Â min vs. 732Â min) | No differences. |
Pourali et al., 2018 [24] | 120 25 mcg sublingually every 4Â h. | The interval between induction and active labor. | No difference in the interval from induction until active labor. (249 vs. 230Â min) | Shorter duration of active labor and second stage of labor. Less PPH More side effects | Improved 5Â min APGAR scores. |
Freret et al., 2021 [25] | 65 Nuliparas only 50mcg buccaly every 4Â h. | Time from admission till delivery | Longer admission to delivery (1194Â min vs. 1014Â min) | No differences in mode of delivery | No differences |
Unthanan et al., 20,222 [26] | 85 Sublingual 25mcg every 2Â h. | Induction to delivery interval | Shorter duration from induction to delivery 338 vs. 399Â min | Reduced cesarean delivery rate Less hyperstimulation and tachysystole | No difference |
Ahmed et al., 2023 [27] | 173 Oral 25 mcg every 4Â h. | Vaginal delivery within 24Â h of PROM | No difference in the rate of the primary outcome (82% vs. 87%) | No difference in the mod of delivery Shorter interval from induction to delivery (450Â min vs. 504Â min) | No differences. |
Ashkenazi Katz et al., 2024 | 493 Oral 50 mcg every 4Â h. | Vaginal delivery within 24Â h of PROM. | Lower rate of vaginal delivery within 24Â h (76.3%vs 87.5%) | Longer duration from PROM and induction until delivery Less time in labor ward No increased risk of cesarean delivery. Lower risk of PPH. | No difference |