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Table 1 Characteristics of GDM patients with and without PTB

From: Association between area under the curve of oral glucose tolerance test and the risk of preterm birth among women with gestational diabetes mellitus: a mediation effect of gestational weight gain

Variables

Total

n = 1860

Non-PTB

n = 1728

PTB

n = 132

P

Maternal age, years, Mean ± SD

30.32 ± 3.77

30.28 ± 3.77

30.84 ± 3.69

0.097

Age group, n (%)

   

0.179

 < 30

863(46.4)

812(47.0)

51(38.6)

 

 30–35

728(39.1)

669(38.7)

59(44.7)

 

 ≥ 35

269(14.5)

247(14.3)

22(16.7)

 

Education, n (%)

   

0.663

 Up to high school

381(20.5)

352(20.4)

19(22.0)

 

 College or higher

1478(79.5)

1375(79.6)

103(78.0)

 

Gravidity, n (%)

   

0.145

 1

817(43.9)

751(43.5)

66(50.0)

 

 ≥ 2

1043(56.1)

977(56.5)

66(50.0)

 

Nulliparity, n (%)

   

0.028

 No

642(34.5)

608(35.2)

34(25.7)

 

 Yes

1218(66.5)

1120(64.8)

98(74.3)

 

DM Family history, n (%)

   

0.257

 No

1661(89.3)

1547(89.5)

114(86.4)

 

 Yes

199(10.7)

181(10.5)

18(13.6)

 

Pre-pregnancy BW, kg, Mean ± SD

55.01 ± 7.80

55.05 ± 7.80

54.44 ± 7.79

0.389

Pre-pregnancy BMI, kg/m2, Mean ± SD

21.76 ± 2.80

21.76 ± 2.81

21.68 ± 2.73

0.742

Pre-pregnancy BMI group, n (%) a

   

0.702

 Underweight

195(10.5)

183(10.6)

12(9.1)

 

 Normal weight

1424(76.5)

1319(76.3)

105(79.5)

 

 Overweight or obesity

241(13.0)

226(13.1)

15(11.4)

 

TC, mmol/L, Mean ± SD

4.42 ± 0.78

4.42 ± 0.78

4.48 ± 0.79

0.372

HDL-c, mmol/L, Mean ± SD

1.70 ± 0.37

1.70 ± 0.37

1.73 ± 0.37

0.381

LDL-c, mmol/L, Mean ± SD

2.19 ± 0.57

2.19 ± 0.57

2.19 ± 0.58

0.865

TG, mmol/L, Mean ± SD

1.37 ± 0.61

1.37 ± 0.61

1.43 ± 0.63

0.233

Early FPG, mmol/L, Mean ± SD

4.67 ± 0.38

4.67 ± 0.38

4.64 ± 0.38

0.301

Gestational age for OGTT, weeks, Mean ± SD

25.75 ± 1.05

25.76 ± 1.06

25.64 ± 0.96

0.186

OGTT0, mmol/L, Mean ± SD

4.70 ± 0.46

4.70 ± 0.46

4.77 ± 0.51

0.095

OGTT1, mmol/L, Mean ± SD

9.85 ± 1.35

9.84 ± 1.33

9.98 ± 1.56

0.265

OGTT2, mmol/L, Mean ± SD

8.74 ± 1.18

8.72 ± 1.19

8.92 ± 1.13

0.062

OGTT0 group, n (%)

   

0.664

 < 5.1

1465(78.8)

1363(78.9)

101(77.3)

 

 ≥ 5.1

395(21.2)

365(21.1)

30(22.7)

 

OGTT1 group, n (%)

   

0.547

 < 10

869(46.7)

804(46.5)

65(49.2)

 

 ≥ 10

991(53.3)

924(53.5)

67(50.8)

 

OGTT2 group, n (%)

   

0.365

 < 8.5

558(30.0)

523(30.3)

35(26.5)

 

 ≥ 8.5

1302(70.0)

1205(69.7)

110(73.5)

 

GWG, kg, Mean ± SD

11.25 ± 4.09

11.40 ± 4.06

9.31 ± 3.99

< 0.001

GWG group, n (%)

   

< 0.001

 Adequate

668(35.9)

632(36.6)

36(27.3)

 

 Insufficient

935(50.3)

845(48.9)

90(68.2)

 

 Excessive

257(13.8)

251(14.5)

6(4.5)

 

ART, n (%)

   

0.014

 No

1772(95.3)

1652(95.6)

120(90.9)

 

 Yes

88(4.7)

76(4.4)

12(9.1)

 

Delivery mode, n (%)

   

0.108

 Vaginal delivery

1082(58.2)

1014(58.7)

68(51.5)

 

 Cesarean Delivery

778(41.8)

714(41.3)

64(48.5)

 

PROM

   

< 0.001

 No

1424(76.6)

1366(79.1)

58(43.9)

 

 Yes

436(23.4)

362(20.9)

74(56.1)

 

Birth height, cm, Mean ± SD

48.83 ± 2.61

49.10 ± 2.31

45.30 ± 3.58

< 0.001

Birth weight, g, Mean ± SD

3179.62 ± 447.15

3234.60 ± 396.62

2459.81 ± 449.02

< 0.001

Macrosomia, n (%)

   

0.103

 No

1813(97.5)

1681(97.5)

132(100.0)

 

 Yes

47(2.5)

47(2.7)

0(0.0)

 

LBW, n (%)

   

< 0.001

 No

1760(94.6)

1685(97.5)

75(56.8)

 

 Yes

100(5.4)

43(2.5)

57(43.2)

 
  1. Abbreviations: GDM, gestational diabetes mellitus; PTB, preterm birth; DM, diabetes mellitus; BW, body weight; BMI, body mass index; TC, total cholesterol; HDL-c, high-density lipoprotein cholesterol; LDL-c, low-density lipoprotein cholesterol; TG, triglyceride; Early FPG, fasting plasma glucose before 13 weeks of gestation; OGTT, oral glucose tolerance test; GWG, gestational weight gain; ART, assisted reproductive technology; LBW, low birth weight
  2. a Underweight (BMI < 18.5 kg/m2), Normal weight (18.5 ≤ BMI < 25 kg/m2), Overweight or obesity (BMI ≥ 25 kg/m2)