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Fig. 5 | BMC Pregnancy and Childbirth

Fig. 5

From: LC-MS/MS assay to confirm that the endogenous metabolite L-Arginine promotes trophoblast invasion in the placenta accreta spectrum through upregulation of the GPRC6A/PI3K/AKT pathway

Fig. 5

L-Arginine promotes trophoblast invasion in placental implantation by activating the GPRC6A/PI3K/AKT axis. A. RT-qPCR detection to detect GPRC6A expression. B. CCK8 to detect cell proliferation. C. Cell scratch assay to detect cell migration. D. Transwell assay to detect cell invasion. E. Western blot to detect p-PI3K, PI3K, p-AKT, AKT, GPRC6A, MMP2, and MMP9 expression. *p < 0.05 vs. L-Arginine. #p < 0.05 vs. L-Arginine + si-NC

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BMC Pregnancy and Childbirth

ISSN: 1471-2393

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