Table 2 The sequences and background information of vitamin D receptor (VDR) gene variants included in the study
Single Nucleotide Polymorphisms (SNP) | Variant sequences | size | Alleles | Gene location on chromosomes | Chromosomal position | Position on gene | Function |
|---|---|---|---|---|---|---|---|
rs2228570 (FokI) | Forward 5’-CTGGCACTGACTCTGGCTCT-3’ Reverse 5’-GTCAGGCAGGGAAGTGCTG-3’ | 86 | C˃T | Exon 2 | Chr12:47879112 | g.30920 T˃C | Met-Thr |
rs1544410 (BsmI) | Forward 5’-GGAACTAGATAAGCAGGGTTCC-3’ Reverse 5’-TAACAGGAATGTTGAGCCCAGT-3’ | 99 | G˃A | Intron 8 | Chr12:47846052 | g.63980G˃A | Non-coding |
rs7975232 (ApaI) | Forward 5’-GGGATAGAGAAGAAGGCACAGG-3’ Reverse 5’-CTGCCGTTGAGTGTCTGTGTG-3’ | 89 | T˃G | Intron 8 | Chr12:47845054 | g.64978G˃T | Non-coding |
rs731236 (TaqI) | Forward 5’-GTGCCCACAGATCGTCCT-3’ Reverse 5’-GGATGTACGTCTGCAGTGTGTT-3’ | 88 | T˃C | Exon 9 | Chr12:47844974 | g.65058 T˃C | Ile-Ile |