Live birth rate and perinatal outcomes following sequential embryo transfer in women with recurrent implantation failure undergoing frozen-thawed embryo transfer cycles

Table 1 Logistic regression analyses on the birth outcomes

Variable	Live birth		Healthy birth		Twin birth
Variable	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value
Protocol of embryo transfer		0.092		0.707		0.707
Seq-ET	Ref		Ref		Ref
D3-dET	0.67 (0.36, 0.97)	0.034	0.81 (0.54, 1.24)	0.333	1.23 (0.57, 2.64)	0.595
D5/6-dET	0.80 (0.54, 1.18)	0.260	0.80 (0.52, 1.24)	0.327	1.39 (0.64, 3.02)	0.407
Female age (y)	0.96 (0.92, 1.00)	0.073	1.00 (0.95, 1.05)	0.975	0.95 (0.85, 1.06)	0.368
Male age (y)	0.99 (0.95, 1.02)	0.491	0.97 (0.93, 1.01)	0.104	0.96 (0.87, 1.06)	0.404
Female BMI (kg/m²)	0.96 (0.92, 1.00)	0.040	0.96 (0.92, 1.01)	0.099	0.96 (0.88, 1.05)	0.358
Infertility duration (y)	0.94 (0.93, 1.02)	0.240	0.98 (0.94, 1.03)	0.471	1.02 (0.92, 1.13)	0.692
Infertility type
Primary infertility	Ref		Ref		Ref
Secondary infertility	0.03 (0.78, 1.35)	0.857	1.06 (0.78, 1.44)	0.720	0.69 (0.39, 1.24)	0.217
Previous failed cycles (n)	1.02 (0.95, 1.10)	0.551	1.00 (0.92, 1.08)	1.000	1.06 (0.92, 1.22)	0.438
Fertilization method
IVF	Ref		Ref		Ref
ICSI	1.00 (0.76, 1.33)	0.981	0.90 (0.66, 1.24)	0.525	0.90 (0.51, 1.59)	0.712
Endometrial preparation method		0.016		0.286		0.327
Natural cycle	Ref		Ref		Ref
Artificial cycle	0.77 (0.59, 1.00)	0.053	0.84 (0.62, (1.12)	0.235	0.84 (0.50, 1.42)	0.508
Stimulation cycle	0.47 (0.26, 0.84)	0.010	0.65 (0.35, 1.22)	0.183	0.22 (0.03, 1.76)	0.155
Endometrial thickness (mm)	1.08 (1.00, 1.16)	0.042	1.10 (1.02, 1.19)	0.018	0.89 (0.76, 1.05)	0.169

ISSN: 1471-2393