Fig. 2

Analysis of differentially expressed metabolites related with PE. A. Volcano plot of differentially expressed metabolites and associated P values and log2 fold change values for EPE patients. The dashed line represents P value < 0.05. Down, Ns, Up denote down-regulated, not significant, up-regulated metabolites respectively. ****: p < 0.0001. B-F. The expression differences of top five most differentially expressed metabolites between EPE patients and controls. G. the KEGG pathways significantly enriched for differentially expressed metabolites in the EPE cohort. H. Volcano plot of differentially expressed metabolites and associated P values and log2 fold change values for LPE patients. I-M. The expression differences of top five most differentially expressed metabolites between LPE patients and healthy controls (***: p < 0.001, ****: p < 0.0001). N. the KEGG pathways significantly enriched for differentially expressed metabolites in the LPE cohort