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Table 2 Meta-analysis of the effects of misoprostol administration on delivery and neonatal outcomes compared with Oxytocin

From: Efficacy and safety of misoprostol versus oxytocin for labor induction in women with prelabor rupture of membranes: a meta-analysis

Outcomes

Test of Association and difference

Test of Heterogeneity

Statistical Model

Test of Publication Bias

P value

Sensitivity Analysis

GRADE Quality score

Pooled effects (95% CI)

P

I2 (%)

P

Begg’s test

Egger’s test

Pooled effects (95% CI) min

Pooled effects (95% CI) max

 

Vaginal birth within 24 h

OR: 0.87 (0.57, 1.32)

0.502

0

0.616

Fixed

0.308

0.175

OR: 0.70 (0.40, 1.22)

OR: 0.94 (0.60, 1.49)

Moderate#

Induction to delivery interval (min)

WMD: -62.82 (-110.56, -15.08)

0.010

86.0

< 0.001

Random

0.827

0.825

WMD: -76.45 (-120.86, -32.03)

WMD: -48.92 (-95.04, -2.80)

Moderate‡

Duration of second stage of labor (min)

WMD: -4.29 (-8.05, -0.52)

0.026

67.2

0.006

Random

0.548

0.441

WMD: -7.33 (-16.36, 1.70)

WMD: -2.56 (-3.57, -1.55)

Moderate‡

Induction to active labor (min)

WMD: 3.48 (-66.45, 73.41)

0.922

89.5

< 0.001

Random

0.462

0.370

WMD: -33.90 (-76.54, 8.75)

WMD: 25.46 (-49.72, 100.64)

Low#‡

Rate of cesarean delivery

OR: 0.93 (0.75, 1.15)

0.489

0

0.523

Fixed

0.620

0.754

OR: 0.89 (0.72, 1.11)

OR: 0.96 (0.77, 1.20)

Moderate#

Uterine hyperstimulation

OR: 1.12 (0.80, 1.56)

0.514

29.9

0.153

Fixed

0.373

0.423

OR: 0.89 (0.72, 1.11)

OR: 1.00 (0.70, 1.43)

Moderate#

Tachysystole

OR: 1.19 (0.85, 1.67)

0.304

48.0

0.044

Fixed

> 0.999

0.885

OR: 1.03 (0.71, 1.50)

OR: 1.39 (0.97, 2.00)

Moderate#

Postpartum hemorrhage

OR: 0.63 (0.41, 0.98)

0.038

0

0.569

Fixed

0.073

0.058

OR: 0.59 (0.37, 0.92)

OR: 0.73 (0.43, 1.26)

Moderate‡

Chorioamnionitis

OR: 1.21 (0.65, 2.25)

0.556

0

0.611

Fixed

0.806

0.461

OR: 0.77 (0.30, 2.00)

OR: 1.37 (0.71, 2.66)

Moderate#

NICU admission

OR: 0.99 (0.74, 1.34)

0.968

0

0.710

Fixed

0.024

0.064

OR: 0.95 (0.69, 1.32)

OR: 1.10 (0.78,1.56)

Low#*

Apgar score at 1 min < 7

OR: 1.12 (0.80, 1.56)

0.514

29.9

0.153

Fixed

0.373

0.423

OR: 1.00 (0.70, 1.43)

OR: 1.34 (0.94, 1.91)

Moderate#

Apgar score at 1 min

WMD: -0.004 (-0.11, 0.10)

0.946

0

0.488

Fixed

0.133

0.159

WMD: -0.05 (-0.20, 0.10)

WMD: 0.02 (-0.09, 0.13)

Moderate#

Apgar score at 5 min < 7

OR: 0.75 (0.36, 1.56)

0.440

0

0.888

Fixed

0.536

0.655

OR: 0.63 (0.29, 1.36)

OR: 0.83 (0.37, 1.87)

Moderate#

Apgar score at 5 min

WMD: 0.07 (-0.12, 0.26)

0.465

83.1

< 0.001

Random

0.548

0.588

WMD: -0.01 (-0.06, 0.03)

WMD: 0.09 (-0.11, 0.30)

Low#‡

Cord pH < 7.1

OR: 0.74 (0.16, 3.37)

0.695

0

0.630

Fixed

> 0.999

N/A

OR: 0.47 (0.04, 5.32)

OR: 1.02 (0.14, 7.52)

Moderate#

Cord pH

WMD: 0 (-0.01, 0.01)

0.992

0

0.450

Fixed

> 0.999

0.990

WMD: -0.003 (-0.01, 0.01)

WMD: 0.004 (-0.01, 0.02)

Moderate#

Meconium-stained liquor

OR: 1.23 (0.90, 1.67)

0.202

0

0.934

Fixed

> 0.999

0.859

OR: 1.14 (0.78, 1.66)

OR: 1.37 (0.97, 1.93)

Moderate#

  1. CI, confidence interval; NICU, neonatal intensive care unit; OR, odds ratio; WMD, weighted mean difference. Significant results (P < 0.05) are marked in bold. # Rated down for serious imprecision; * Rated down for publication bias; ‡ Rated down for inconsistency
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BMC Pregnancy and Childbirth

ISSN: 1471-2393

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