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Table 4 Diagnostic performance of NQO1-AS and NQO1-MS for DS prediction

From: Oxidative stress biomarkers as novel screening tools for trisomy 21: a case-control study

Parameter

NQO1-AS

NQO1-MS

AUC (95% CI)

0.82 (0.74–0.90)

0.78 (0.69–0.87)

Cut-off value (ng/ml)

800

650

Sensitivity (%)

85

80

Specificity (%)

75

70

Positive Predictive Value (%)

77

73

Negative Predictive Value (%)

83

78

Accuracy (%)

80

75

  1. NQO1: NAD(P)H dehydrogenase [quinone] 1, AS: amniotic serum, MS: maternal serum, DS: Down syndrome, AUC: Area Under the Curve
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BMC Pregnancy and Childbirth

ISSN: 1471-2393

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