Oxidative stress biomarkers as novel screening tools for trisomy 21: a case-control study

Table 7 Multiple logistic regression analysis for DS prediction

Biomarker	Odds Ratio (95% CI)	P value	Standardized Coefficient
NQO1-AS	3.82 (1.94–7.51)	< 0.001	0.684
NQO1-MS	2.95 (1.48–5.87)	< 0.001	0.542
CSE-MS	1.89 (1.01–3.54)	0.049	0.328
NRF2-AS	0.45 (0.22–0.92)	0.029	-0.294
NRF2-MS	0.52 (0.30–0.91)	0.022	-0.276
NFKB-AS	1.12 (0.49–2.56)	0.783	0.048
NFKB-MS	1.45 (0.84–2.51)	0.178	0.156
CSE-AS	1.38 (0.77–2.48)	0.280	0.142

AS: amniotic serum, MS: maternal serum, NQO1: NAD(P)H dehydrogenase [quinone] 1, NRF2: nuclear factor erythroid 2-related factor 2, NFKB: nuclear factor-kappa B, CSE: cystathionine-γ-lyase, DS: Down syndrome, CI: Confidence Interval
Odds ratios are adjusted for all variables in the model

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