From: Pharmacological pain relief and women´s birth experience: a systematic review
Author Year | Country | Sample size Study design | Study population | Intervention (% of total) and comparator | Birth Experience ¤ | Assessment tool #/ time of assessment post-partum | Comments |
---|---|---|---|---|---|---|---|
Higher maternal satisfaction with pharmacological pain relief | |||||||
Orange [56] 2012 | Brazil | 70 Randomized controlled study | P*and NP** Term pregnancies 100% vaginal births. Mean age 22 years. | Combined spinal epidural analgesia (CSE) (50%) compared to non-pharmacological pain relief | Higher maternal satisfaction among women receiving combined spinal epidural analgesia (CSE) | 1–5 Likert scale / immediately | No statistically significant difference between groups in rate of CS##, instrumental birth, oxytocin induction, duration of expulsion phase or neonatal outcomes |
Liu [70] 2021 | China | 4192 Cross sectional study | P* and NP** Gestational age > 32 weeks. 100% vaginal births Mean age 29,8 years | Epidural analgesia (EDA§) (75,6%) compared to no EDA§ | Higher maternal satisfaction among women receiving epidural analgesia (EDA§) | 1–10 Likert scale /2–3 h | Duola or family member present, use of breathing technique and warm perineal compress were other factors associated with higher maternal satisfaction |
Lower maternal satisfaction with pharmacological pain relief | |||||||
Börjesson [66] 2007 | Sweden | 518 Prospective co-hort study | NP** 89% Vaginal births. Mean age 27,2 years | EDA§ (65%) compared to no EDA§ | Higher odds for a negative birth experience among women receiving EDA§ | VAS 1–100 mm /within 3 months | Elective CS## were excluded. Other modes of delivery than unassisted vaginal birth were associated with a higher risk of a negative birth experience |
Fenaroli [65] 2019 | Italy | 111 Prospective longitudinal study | NP** Term pregnancies. 80.6% vaginal births. Mean age 32 years | EDA§ (45,4%) compared to no EDA§ | Less positive birth experience among women receiving EDA§ | W-DEQ (B) # / 1–5 days | Elective CS## were excluded No significant association between birth experience and mode of delivery or induction of labor |
Fernández-Arranz [64] 2019 | Spain | 89 Randomized controlled study | P* and NP** 100% Vaginal births. Mean age 32,9 years | Haloperidol and Pethidine (49%) compared to use of birthing ball | Lower maternal satisfaction among women who received Haloperidol and Pethidine | Mackey Satisfaction Childbirth Rating Scale # /before discharge | No blinding of participants or investigators |
Fumagalli [71] 2021 | Italy | 277 Cross sectional study | P* and NP**. Term pregnancies. 94,4% vaginal births. Mean age 33 years | EDA§ (32%) compared to no EDA§ | Lower maternal satisfaction among women who received EDA§ | BSS-R # /before discharge | Active phase of labor > 12 h and vacuum assisted birth was associated with a lower birth satisfaction |
Johansson [68] 2019 | Sweden | 584 Cross sectional study | NP** 86.5% vaginal births. Mean age 29 years | EDA§ (35%) compared to no EDA§ | Higher odds for a negative birth experience among women receiving EDA§ | 1–10 Likert scale / immediately | Oxytocin induction significantly associated with use of EDA§ Mixed groups: Morphine, nitrous oxide and EDA§ not separated |
Lathrop [73] 2018 | USA | 122 Case control study | P* and NP** Term pregnancies 100% vaginal births Age > 18 years | EDA§ (46%) compared to water birth | Less positive childbirth experience among women receiving EDA§ | CEQ # / 1–7 days | Primary aim of study was to explore benefits with water birth compared to conventional birth |
Lindholm [61] 2015 | Sweden | 866 Prospective longitudinal study | P* and NP** 82% vaginal births. Majority aged 25–35 years | EDA§ (32%) compared to no EDA§ Nitrous oxide (85%) compared to no nitrous oxide | Less positive birth experience among women receiving EDA§ No association found between nitrous oxide and birth experience | 1–5 Likert scale / 2 months | Elective CS## were excluded. Primary aim of study was to identify factors associated with preferred pain relief methods |
Lyngbye [62] 2022 | Denmark | 201 Prospective cohort-study | P* and NP** Term pregnancies 92% vaginal births Mean age 29,2 years | EDA§ (26,7%) compared to no EDA§ Nitrous oxide (47%) compared to no nitrous oxide | Use of EDA§ was associated with a led positive childbirth experience Use of nitrous oxide was associated with a less positive childbirth experience | CEQ # /6 weeks | 52% of the women reported a lower satisfaction score after 6 weeks compared to after 1 week |
Nystedt [74] 2018 | Sweden | 928 Cross sectional study | P* and NP** Uncomplicated pregnancies 82% vaginal deliveries Majority aged 25–35 years | Obstetric analgesia (31%) compared to no obstetric analgesia | Higher odds for a negative birth experience among women receiving obstetric analgesia | Likert scale 1–5 /2 months | No definition of the term “obstetric analgesia” Other modes of delivery than unassisted vaginal birth, were associated with a higher risk of a negative birth experience |
Waldenström [57] 1999 | Sweden | 1111 Prospective longitudinal study | P* and NP** 84.3% vaginal deliveries. Mean age 30 years | Nitrous oxide (33%) compared to no nitrous oxide | Use of nitrous oxide was associated with a a negative birth | Likert scale 1–7 / 2 months | No association found for EDA§ or Pethidine Mixed groups: EDA§, Pethidine and Nitrous oxide not separated |
Waldenström [13] 2004 | Sweden | 2541 Prospective longitudinal study | P* and NP** 92% vaginal births. Mean age 29.5 years | EDA§ (30%) compared to no EDA§ | Higher risk for a negative birth experience among women receiving EDA§. | Likert scale 1–7# / 2 months | Emergency CS##, instrumental birth, induction, strong pain, not part of decision-making and child to neonatal unit were correlated to a risk of a negative birth experience |
Weeks [69] 2017 | Chile | 1534 Cross sectional study | P* and NP**. 80% vaginal births Age 18–32 years | Pharmacological pain management (74%, nitrous oxide or EDA§) compared to no pharmacological pain management | Lower maternal satisfaction among women receiving pharmacological pain management | Maternal well-being scale, by Uribe et al. 42-questions # / 1–2 days | CS##, continuous monitoring of fetal heartbeat and episiotomy were associated with a lower maternal satisfaction |
No association found between maternal satisfaction and pharmacological pain relief | |||||||
Larsson [37] 2011 | Sweden | 280 Prospective longitudinal study | NP** at term. 56% vaginal births Age not supplied | EDA§ (26,3%) compared to no EDA§ | No association found between EDA§ and birth experience | W-DEQ (B)# / 9 months | Secondary aim of study was to compare the assessment tools W-DEQ (B) and VAS Mixed population, evaluating both vaginal births and caesarean section |
Rijnders [67] 2008 | Netherlands | 1293 Retrospective cohort study | P* and NP** 86.9% vaginal births Mean age 31 years | Pain relief (14%) compared to no pain relief | No association found between pain relief and recall of birth experience | One question from “Greater Expectations” # / 3 years | Assisted vaginal, non-elective CS##, referral during birth, no choice of pain relief and dissatisfaction with coping with pain were associated with a negative recall of child-birth No information supplied regarding type of pain relief |
Spaich [44] 2013 | Germany | 335 Prospective longitudinal study | P* and NP**. At term pregnancies. 65% vaginal birth. Median age 31 years | Intravenous pain medication and EDA§ compared to no pain relief | No association found between pharmacological pain relief and birth experience | Salmon Item List# /Before discharge from hospital | High level of pain perception was associated with risk for a negative experience No significant association found between mode of delivery and birth experience |
Such [63] 2021 | USA | 84 Cross sectional study | P* and NP**. At term Uncomplicated pregnancies. 100% vaginal births. Age > 18 years. | EDA§ (33%) compared to no epidural analgesia Nitrous oxide (33%) compared to no nitrous oxide | No significant difference in satisfaction with birth experience between groups No significant difference in satisfaction with birth experience between groups | BSS-R# /within 6 h | Income and education were independently associated with a higher birth satisfaction score |