Fig. 1

Workflow of the study. A series of analyses were conducted to identify potential pathogenic genes associated with the development of Pre-eclampsia (PE) and Pregnancy Hypertension (PH). Cis-eQTL data for Blood were obtained from the eQTLGen consortium, while cis-eQTL data for Artery Aorta, Uterus, and Kidney Cortex were extracted from the GTEx database as exposure datasets. GWAS summary data for PE and PH were obtained from the FinnGen R10 database as outcome datasets, including cases with PE or PH and healthy controls. SMR, HEIDI, and FDR analyses were performed to integrate cis-eQTLs from Blood, Artery Aorta, Uterus, and Kidney Cortex with GWAS data for PE, and cis-eQTLs from Blood, Artery Aorta, and Uterus with GWAS data for PH. Genes satisfying the criteria of SMR p < 0.05, HEIDI p > 0.05, and FDR p < 0.05 were considered potential pathogenic genes. GO and KEGG enrichment analyses were conducted to further explore the biological functions and pathways associated with potential pathogenic genes in PE and PH