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Table 1 CBD-related prevalence from 1990 to 2021 by SDI and GBD2021 regions

From: Global, regional, and national epidemiology of congenital birth defects in children from 1990 to 2021: a cross-sectional study

Location

Prevalent cases (95% UI)×1,000,000

Prevalence/100,000 (95% UI)

EAPC of prevalence (95% CI)

Cases change (%, 95% UI)

1990

2021

1990

2021

1990–2021

Global

29.66 (26.71–32.89)

31.64 (28.44–35.16)

1705.17 (1535.59-1891.43)

1572.51 (1413.66-1747.51)

-0.17 (-0.21–0.13)

6.68 (4.96–8.39)

SDI region

      

High SDI

3.10 (2.84–3.40)

2.62 (2.41–2.86)

1669.14 (1529.70-1829.44)

1520.55 (1395.90-1660.09)

-0.23 (-0.26–0.19)

-15.41 (-16.75–14.05)

High-middle SDI

4.67 (4.23–5.13)

3.49 (3.17–3.81)

1705.94 (1546.74-1875.12)

1511.15 (1374.74-1648.25)

-0.12 (-0.22–0.02)

-25.25 (-26.98–23.50)

Middle SDI

9.19 (8.27–10.22)

8.21 (7.40–9.07)

1591.72 (1432.68-1770.41)

1449.05 (1305.69-1600.14)

-0.15 (-0.21–0.10)

-10.60 (-12.38–8.64)

Low-middle SDI

8.41 (7.54–9.41)

9.50 (8.51–10.64)

1781.40 (1597.44-1992.38)

1637.60 (1467.59-1834.29)

-0.24 (-0.26–0.21)

12.90 (11.07–14.76)

Low SDI

4.27 (3.81–4.77)

7.79 (6.94–8.68)

1863.54 (1666.54-2083.25)

1693.02 (1507.46-1886.60)

-0.33 (-0.37–0.30)

82.65 (79.49–85.92)

GBD region

      

Andean Latin America

0.21 (0.19–0.23)

0.25 (0.23–0.28)

1408.00 (1254.73-1574.25)

1400.71 (1268.35-1538.90)

-0.00 (-0.04-0.03)

21.20 (17.13–25.66)

Australasia

0.07 (0.07–0.08)

0.08 (0.07–0.09)

1573.59 (1438.06-1723.79)

1433.36 (1307.20-1566.21)

-0.26 (-0.30–0.23)

13.83 (9.27–18.45)

Caribbean

0.18 (0.16–0.19)

0.18 (0.16–0.20)

1556.53 (1401.43-1720.16)

1557.62 (1397.37-1731.66)

0.03 (0.01–0.05)

0.88 (-1.73-3.28)

Central Asia

0.48 (0.43–0.52)

0.53 (0.48–0.58)

1911.88 (1737.64-2090.35)

1920.64 (1747.94-2108.09)

0.24 (0.11–0.36)

11.25 (9.02–13.35)

Central Europe

0.43 (0.40–0.48)

0.26 (0.23–0.28)

1470.99 (1347.30-1612.53)

1440.96 (1318.51-1585.17)

0.04 (-0.01-0.09)

-41.19 (-42.32–40.11)

Central Latin America

1.37 (1.17–1.60)

1.24 (1.07–1.42)

2134.26 (1825.06-2486.83)

1945.78 (1688.22-2233.08)

-0.32 (-0.34–0.30)

-10.10 (-12.73–7.43)

Central Sub-Saharan Africa

0.48 (0.43–0.53)

0.98 (0.88–1.10)

1899.52 (1697.78-2111.35)

1671.70 (1494.89-1874.66)

-0.40 (-0.46–0.33)

104.14 (96.93-111.15)

East Asia

4.90 (4.42–5.42)

3.26 (2.97–3.57)

1485.37 (1340.25-1642.96)

1221.00 (1110.91-1334.97)

-0.28 (-0.40–0.16)

-33.37 (-35.90–30.72)

Eastern Europe

1.02 (0.92–1.12)

0.62 (0.57–0.68)

1979.09 (1796.09-2169.36)

1757.52 (1597.95-1925.24)

-0.01 (-0.17-0.15)

-38.84 (-39.93–37.72)

Eastern Sub-Saharan Africa

1.63 (1.46–1.82)

2.84 (2.53–3.17)

1797.19 (1612.98-2007.69)

1590.25 (1417.25-1775.34)

-0.41 (-0.45–0.38)

74.32 (70.43–78.19)

High-income Asia Pacific

0.83 (0.72–0.95)

0.50 (0.44–0.57)

2356.98 (2056.22-2689.81)

2232.91 (1953.00-2543.14)

-0.19 (-0.22–0.15)

-39.64 (-41.63–37.54)

High-income North America

0.86 (0.79–0.95)

0.82 (0.75–0.88)

1398.03 (1274.76-1536.09)

1246.81 (1146.74-1347.65)

-0.29 (-0.35–0.23)

-5.12 (-8.06–2.37)

North Africa and Middle East

2.61 (2.36–2.90)

3.11 (2.81–3.44)

1859.05 (1682.40-2061.97)

1699.16 (1535.23-1878.34)

-0.18 (-0.24–0.12)

19.27 (16.98–21.63)

Oceania

0.04 (0.03–0.04)

0.07 (0.07–0.08)

1364.55 (1234.04-1507.10)

1470.76 (1330.23-1636.70)

0.27 (0.25–0.29)

104.35 (97.50-110.69)

South Asia

7.86 (7.02–8.87)

8.29 (7.40–9.43)

1814.24 (1619.77-2047.68)

1635.47 (1460.42-1860.19)

-0.31 (-0.33–0.28)

5.47 (3.56–7.51)

Southeast Asia

2.46 (2.19–2.78)

2.37 (2.11–2.67)

1440.89 (1280.97-1626.15)

1374.41 (1222.85-1545.70)

-0.13 (-0.15–0.11)

-3.55 (-5.07–1.83)

Southern Latin America

0.25 (0.22–0.28)

0.24 (0.22–0.27)

1672.42 (1492.87-1865.79)

1669.10 (1495.34-1853.31)

0.16 (0.08–0.24)

-3.08 (-7.13-1.19)

Southern Sub-Saharan Africa

0.34 (0.30–0.37)

0.38 (0.35–0.42)

1622.05 (1473.77-1778.37)

1596.86 (1446.39-1758.03)

0.07 (-0.00-0.13)

14.51 (12.06–17.07)

Tropical Latin America

0.80 (0.73–0.87)

0.73 (0.66–0.80)

1491.34 (1366.92-1615.17)

1444.80 (1311.20-1589.96)

-0.07 (-0.09–0.05)

-9.30 (-12.81–5.62)

Western Europe

1.19 (1.10–1.29)

1.12 (1.03–1.23)

1681.90 (1553.01-1817.58)

1651.30 (1514.51-1807.69)

0.01 (-0.03-0.06)

-5.83 (-8.34–3.53)

Western Sub-Saharan Africa

1.64 (1.47–1.83)

3.74 (3.34–4.18)

1869.65 (1672.04-2087.65)

1743.46 (1556.77-1946.85)

-0.26 (-0.32–0.20)

127.89 (124.53-131.56)

  1. Abbreviations: CBD, congenital birth defect; CI, confidence interval; EAPC, estimated annual percentage change, expressed as 95% CI; GBD, Global Burden of Disease; SDI, sociodemographic index; UI, uncertainty interval