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Table 2 Maternal outcomes of 4 groups

From: Preterm birth and stillbirth: total bile acid levels in intrahepatic cholestasis of pregnancy and outcomes of twin pregnancies: a retrospective cohort study from 2014 to 2022

Description

mild(n = 430)

Moderate-low(n = 392)

Moderate-high ( n = 292)

severe( n = 42)

P-Value

GA at diagnosis, median(P25-P75)

34(31,35) a

32(30,34) b

32(29,33) c

30(27,33)c

0.000

TBA at diagnosis, median(P25-P75)

12.7(11.0,15.4) a

20.0(13.2,26.7) b

39.1(20.4,52.9) c

67.6(24.7,125.2) c

0.000

Vaginal delivery

19(4.4%)a, b

6(1.5%)b

16(5.5%)a

2(4.8%)a, b

0.037

TBA at peak

14.0(12.0,16.7) a

27.6(23.8,32.4) b

56.1(47.8,69.8) c

139.5(116.0,174.7) d

0.000

TBA at delivery, median(P25-P75)

11.2(8.2,14.2) a

20.4(12.4,26.0) b

37.1(20.3,52.2) c

70.5(30.5,111.2) c

0.000

Delivery week, median(P25-P75)

36(34,37) a

35(34,36) a

35(34,36) b

34(33,35) c

0.000

Delivery week 28–31

21(4.9%)a, b

9(2.3%)b

17(5.8%%)a, b

6(14.3%)a

0.002

Delivery week 32–36

296(68.8%)a

311(79.3%)b

250(85.6%)b

33(78.6%)a, b

0.000

Delivery week ≥ 37

110(25.6%)a

72(18.4%)a, b

22(7.5%)c

2(4.8%)b, c

0.000

Preterm birth, n(%)

317(73.7%)a

320(81.6%)b

267(91.4%)c

39(92.9%)b, c

0.000

Intraoperative blood loss, median(P25-P75)

400(400,500)

400(400,600)

400(400,500)

400(400,500)

0.210

Placental abruption, n(%)

7(1.6%)

5(1.3%)

6(2.1%)

0(0%)

0.717

PROM, n(%)

78(18.1%)

67(17.1%)

40(13.7%)

5(11.9%)

0.354

Fetal growth restriction, n(%)

23(5.3%)

9(2.3%)

14(4.8%)

3(7.1%)

0.109

Fetal distress, n(%)

21(4.9%)

17(4.3%)

18(6.2%)

3(7.1%)

0.669

stillbirth, n(%)

8(1.9%)

6(1.5%)

7(2.4%)

0(0%)

0.679

Preeclampsia, n(%)

42(9.8%)

50(12.8%)

37(12.7%)

3(7.1%)

0.382

gestational diabetes, n(%)

117(27.2%)

116(29.6%)

88(30.1%)

10(23.8%)

0.705